![]() ![]() ĭhingra NK, Mistry N, Puar P, Verma R, Anker S, Mazer CD, et al. Impact of dapagliflozin on left ventricular diastolic function of patients with type 2 diabetic mellitus with chronic heart failure. Soga F, Tanaka H, Tatsumi K, Mochizuki Y, Sano H, Toki H, et al. Effect of empagliflozin on left ventricular volumes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF). Lee MMY, Brooksbank KJM, Wetherall K, Mangion K, Roditi G, Campbell RT, et al. Dapagliflozin across the range of ejection fraction in patients with heart failure: A patient-level, pooled meta-analysis of DAPA-HF and DELIVER. Jhund PS, Kondo T, Butt JH, Docherty KF, Claggett BL, Desai AS, et al. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. N-terminal pro-B-type natriuretic peptide (NT-proBNP) showed a significant reduction at 180 days (-18.2%, p < 0.001), without changes in filling Doppler measures.ĭapagliflozin administration in stable out-setting patients with chronic HF and optimized therapy results in global reverse remodelling of cardiac structure, including reductions in LA volumes and improvement in left ventricular geometry and NT-proBNP concentrations.īiomarkers Dapagliflozin Heart failure Left atrium Remodelling. Left ventricular geometry improved with significant reductions in left ventricular mass index (-13.9%, p < 0.001), end-diastolic volume (-8.0%, p < 0.001) and end-systolic volume (-11.9%, p < 0.001) at 180 days. LAVI showed a significant reduction at 180 days (-6.6%, p = 0.008), primarily due to a decrease in reservoir volume (-13.8%, p = 0.007). At baseline, LA dilatation was observed (LAVI 48.1 ± 22.6 ml/m 2 ) and LA parameters were similar between LVEF-based phenotypes (≤40% vs. A total of 162 patients (64.2% men, 70.5 ± 10.6 years, 52% LVEF >40%) were included in the study. The primary endpoint was the change in maximal LA volume index (LAVI). Echocardiography was performed at baseline, 30 and 180 days, and analysed by a central core-lab in a blinded manner to both patient and time. Patients with stable chronic HF receiving optimized guideline-directed therapy, except for any sodium-glucose cotransporter 2 inhibitor, were included. The DAPA-MODA trial ( NCT04707352) is a multicentre, single-arm, open-label, prospective and interventional study that aimed to evaluate the effect of dapagliflozin on cardiac remodelling parameters over 6 months. However, its effect on cardiac remodelling parameters, specifically left atrial (LA) remodelling, is not well established. 14 Cardiology Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.ĭapagliflozin improves the prognosis of patients with heart failure (HF), regardless of left ventricular ejection fraction (LVEF).13 Cardiology Department, Hospital Clínico San Carlos, Madrid, Spain.12 Cardiology Department, Hospital Álvaro Cunqueiro, IIS Galicia Sur, Vigo, Spain.11 Cardiology Department, Hospital Universitario Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.10 Cardiology Department, Hospital Universitario Virgen de la Victoria, Málaga, Spain.9 Cardiology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.8 Cardiology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain.7 Cardiology Department, Hospital de Dénia-MarinaSalud, Denia, Spain.6 Cardiology Department, Hospital Universitari Germans Trias i Pujol.5 Cardiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.4 Centro de Investigación Biomédica en Red, CIBERCV, Madrid, Spain.3 Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.2 Medicine Department, Universidad de Murcia, Murcia, Spain.1 Cardiology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto IMIB-Pascual Parrilla, Murcia, Spain. ![]()
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